What are polynucleotides?

Polynucleotides, often referred to as PNs, are a fascinating component of biological systems. Simply put, they are long chains made up of nucleotide units which are the building blocks of DNA. DNA is essential in genetic information transfer in living organisms. Essentially, Polynucleotide treatments are DNA fragments in a syringe.  

Now, let’s delve into how polynucleotides are sourced for therapeutic use. They are typically derived from natural sources like salmon or trout fish, usually the gonads. The brand of PN I use in my clinic sources their PN from farmed trout in Italy that will be used for human consumption. Through advanced biotechnological processes, these molecules are extracted to harness their potential for aesthetic applications. Mastelliis an Italian company producing PN and use a patented technology known as HPT (high purification technology). They have been established in PN for over 50 years. Dermafocus distribute this brand in the UK and their range is called PLINEST. I use this particular brand in my clinic due to their stringent purification process, extensive knowledge in this field and high safety profiles.

Am I a good candidate for Polynucleotide treatment?

When considering if you are a good candidate for polynucleotide treatments, the ideal individual is someone seeking skin rejuvenation or tissue repair. This means that these treatments can be used both to prevent skin damage or ageing as well as to help repair already damaged/aged skin. These treatments are popular in cosmetic and regenerative medicine due to their incredible ability to enhance skin elasticity andhydration, promote collagen production and stimulate tissue regeneration. 

Is cannula or needle better for administration?

The method of administration, whether through a cannula or a needle, depends on the specific goals of the treatment and the treatment areas, as well as consideration for swelling and bruising which can affect downtime.

 A cannula is a long, thin tube with a rounded, blunt tip. Because the tip is blunt, it may minimise trauma to the tissues, reducing the risk of bruising and discomfort and we can often treat a larger area trough a single entry point. I like to use cannula for a more generalise regenerative treatment or if someone is really concerned about downtime. The downside with cannula is that I cannot be precise with my injections or focus on areas like the upper eyelid to tailor the treatment. There is also a limitation to how superficial I can be in the skin, where ideally we want the PN to be injected.

On the other hand, needles are commonly used when a more targeted and localised approach is needed. We can focus on areas of concern such as eyelids, eyebrows, lines around the mouth, forehead, scalp etc. We have more control over depth with a needle, meaning we can inject the PNs superficially into the skin where they act locally to produce regenerative results. There are multiple injections involved with a needle and while the repeated injections may contribute to a better result, the down side is an increased risk of bruising and small lumps at the injection site that can take up to 48 hours to settle. 

The choice between a cannula and a needle ultimately depends on factors such as the treatment area, the desired outcome, the patient’s comfort level and downtime considerations. I very often use a combined approach of both cannula and needle in the same session for best results.  Discussing these options with a qualified healthcare professional can help determine the most appropriate method for you.

What is the downtime with polynucleotide treatments? 

Now, let’s touch on the downtime associated with polynucleotide treatments. One of the appealing aspects of these procedures is that they often involve minimal downtime compared to more invasive interventions. Patients typically experience mild redness or swelling at the injection site, but these effects are generally temporary and resolve within a few days. Cannula-based treatments often result in less bruising and swelling, contributing to a quicker recovery. Patients can usually resume their daily activities shortly after the procedure. However, it’s essential to follow post-treatment care instructions provided by the healthcare provider to optimise results and minimise any potential side effects. Needle-based treatments may involve a slightly longer recovery period due to the nature of the technique. While the downtime is still relatively short, patients may need to allow a few extra days for any bruising or swelling to subside. 

It’s crucial for individuals considering polynucleotide treatments to have realistic expectations regarding the recovery process. While these procedures are designed to be minimally invasive, the body’s response to the introduction of foreign substances may vary, and some temporary effects should be anticipated. 

In conclusion, polynucleotide treatments offer a promising avenue for those seeking non-invasive solutions for skin rejuvenation and tissue repair. The choice between a cannula and a needle depends on various factors, including the treatment area and individual preferences. With minimal downtime and potential benefits for skin health, these procedures continue to gain popularity in the realm of cosmetic and regenerative medicine. Always consult with a qualified healthcare professional to determine the most suitable approach for your unique needs and goals.